2 Postconditioning of Ischemic Heart by Intermittent 3 Ventricular Pacing at the Beginning of Reperfusion : Novel 4 Mechanisms and Potential Utilities in Interventional 5 Cardiology Settings
نویسندگان
چکیده
Feiyan Yang and Lei Xi 7 1 Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia 8 Commonwealth University, Richmond, Virginia, USA 9 2 Department of Cardiology, Central Hospital of Wuhan, Wuhan, China 10 Total word count: 2523 11 *Address correspondence to: 12 Lei Xi, MD, FAHA 13 Associate Professor 14 Division of Cardiology, Box 980204 15 Virginia Commonwealth University 16 1101 East Marshall Street, Room 7-020C 17 Richmond, VA 23298-0204 18 Phone: (804)-628-5533 19 Fax: (804)-828-8700 20 E-mail: [email protected] 21 22 Articles in PresS. Am J Physiol Heart Circ Physiol (November 13, 2015). doi:10.1152/ajpheart.00835.2015
منابع مشابه
Postconditioning of ischemic heart by intermittent ventricular pacing at the beginning of reperfusion: novel mechanisms and potential utilities in interventional cardiology settings.
SINCE THE FIRST DESCRIPTION of ischemic postconditioning in an in vivo dog model of ischemia-reperfusion (I/R) injury by Dr. Zhi-Qing Zhao and colleagues of Emory University in a seminal paper published in the American Journal of Physiology-Heart and Circulatory Physiology in 2003 (27), this cardioprotective modality has been confirmed in many mammalian species including humans (20) and mice (1...
متن کاملProtective effect of pharmacologic postconditioning with Natural Honey against left ventricular ischemia/reperfusion-induced arrhythmias in isolated heart of rat
Introduction: This study was aimed to investigate the effects of postconditioning by natural honey on cardiac arrhythmias in the ischemic isolated rat heart. Methods: Male Wistar rats were divided into four groups then anesthetized by sodium pentobarbital. The animal hearts were removed and quickly mounted on a Langendorff apparatus and perfused under constant pressure by a modified Krebs-H...
متن کاملIschemic postconditioning: brief ischemia during reperfusion converts persistent ventricular fibrillation into regular rhythm.
OBJECTIVES Brief episodes of myocardial ischemia-reperfusion employed during reperfusion after a prolonged ischemic insult may attenuate the total ischemia-reperfusion injury. This phenomenon has been termed ischemic postconditioning. In the present study, we studied the possible effect of postconditioning on persistent reperfusion-induced ventricular fibrillation (VF) in the isolated rat heart...
متن کاملCombined postconditioning with ischemia and cyclosporine-A restore oxidative stress and histopathological changes in reperfusion injury of diabetic myocardium
Objective(s): Chronic diabetes impedes cardioprotection in reperfusion injury and hence protecting the diabetic heart would have important outcomes. In this study, we evaluated whether combined postconditioning with ischemia and cyclosporine-A can restore oxidative stress and histopathological changes in reperfusion injury of the diabetic myocardium. Materials and Methods: Streptozocin-induced ...
متن کاملCan chronotropic incompetence predict life-threatening ventricular arrhythmias in patients with stable ischemic heart disease?
Background: Chronotropic incompetence has prognostic value of all-cause and cardiovascular mortality in both patients with asymptomatic and symptomatic ischemic heart disease (IHD), regardless of traditional risk factors. The aim of this study was to investigate the relationship between chronotropic response during exercise test and the development of ventricular arrhythmias. Methods: 153 pati...
متن کامل